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Clinical Evidence

The Most Robust Body of Clinical Evidence

No other company has committed so fully to establishing clinical evidence for the safety and efficacy of a spinal cord stimulation (SCS) system. HF10® therapy is backed by two prospective 24-month trials1,2 and a large body of real-world data.3

Long Term Durable Results

The landmark SENZA-RCT2 demonstrated long-term safety and improved efficacy for both back and leg pain with HF10 therapy.

View The Senza-rct
Back Pain
Leg Pain
Back Pain
Leg Pain
Long-Term Responder Rates

Reproducible Real-World Outcomes

In a real-world study, patients achieved a 74% responder rate, mirroring the excellent outcomes of the SENZA-RCT.

View The Publication

HF10 Therapy Provides Significant Reduction in Opioid Intake at Two Years1

Nearly 70% average reduction of morphine-equivalent dose1

Mean Morphine Equivalent Per Patient

1. Al-Kaisy A, Van Buyten J-P, Smet I, Palmisani S, Pang D, Smith T. Sustained effectiveness of 10 kHz high-frequency spinal cord stimulation for patients with chronic, low back pain: 24-month results of a prospective multicenter study. Pain Med. 2014;15:347-354. 2. Kapural L, et al. Comparison of 10-kHz High-Frequency and Traditional Low-Frequency Spinal Cord Stimulation for the Treatment of Chronic Back and Leg Pain: 24-month Results from a Multicenter, Randomized, Controlled Pivotal Trial. Neurosurgery. Published 09 2016 3. Stauss, T, et al. A multicenter real-world review of 10 kHz SCS outcomes for treatment of chronic trunk and/or limb pain. Annals of Clinical and Translational Neurology. Jan. 22, 2019. *Mean time from implant to last visit is nine months.