{"id":112,"date":"2025-03-13T23:04:35","date_gmt":"2025-03-13T23:04:35","guid":{"rendered":"https:\/\/www.nevro-local.com\/en\/publications\/"},"modified":"2025-05-05T22:39:54","modified_gmt":"2025-05-05T22:39:54","slug":"outcomes","status":"publish","type":"page","link":"https:\/\/www.nevro.com\/en\/outcomes\/","title":{"rendered":"Outcomes"},"content":{"rendered":"
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Advancing patient
care with
meaningful
evidence.<\/h1>\r\n \r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n
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The Proof Is In The Patient<\/h1>\r\n

We are committed to developing best-in-class evidence to improve treatment and support patient access. Our evidence portfolio advances the use of spinal cord stimulation for pain areas commonly treated with SCS and expands patient access to new & industry exclusive indications such as pain from diabetic neuropathy.<\/p>\n<\/div>\r\n <\/div>\r\n<\/div>\n\n

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Landmark Publications<\/h2>\r\n

Nevro aims to develop and publish rigorous evidence to support critical decisions made by physicians, regulators and payors.<\/p>\r\n <\/div>\r\n

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SENZA PDN<\/p>\r\n

The largest RCT studying PDN<\/p>\r\n Download<\/a>\r\n <\/div>\r\n

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The SENZA-RCT<\/p>\r\n

The first multicenter, prospective, randomized, controlled pivotal study of an SCS system<\/p>\r\n Download<\/a>\r\n <\/div>\r\n

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Real-world Outcomes<\/p>\r\n

A multicenter real world review of 1,660 10 kHz Therapy<\/p>\r\n Download<\/a>\r\n <\/div>\r\n

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10 kHz Therapy And Opioid Intake<\/p>\r\n

A multi-study analysis of opioid intake<\/p>\r\n Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n

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Highlighted Evidence<\/h1>\r\n
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Chronic Low Back Pain and Leg Pain<\/h3>\r\n <\/div>\r\n
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Author<\/h5><\/div>\r\n
Source<\/h5><\/div>\r\n
Title<\/h5><\/div>\r\n
Download File<\/h5><\/div>\r\n <\/div>\r\n
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Stauss T., et al.<\/p><\/div>\r\n

Annals of Clinical and Translational Neurology 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

A Multicenter Real\u2010world Review Of 10 kHz SCS Outcomes For Treatment Of Chronic Trunk And\/or Limb Pain<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Amirdelfan K., et al.<\/p><\/div>\r\n

Quality of Life Research 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Long-term Quality Of Life Improvement For Chronic Intractable Back And Leg Pain Patients Using Spinal Cord Stimulation: 12-month Results From The SENZA-RCT<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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DiBenedetto D.J., et al.<\/p><\/div>\r\n

Journal of Pain Research 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

10 kHz Spinal Cord Stimulation: A Retrospective Analysis Of Real-World Data From A Community-Based, Interdisciplinary Pain Facility<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Kapural L., et al.<\/p><\/div>\r\n

Neurosurgery 2016<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Comparison Of 10 kHz High-frequency And Traditional Low-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back And Leg Pain: 24-month Results From A Multicenter, Randomized, Controlled Pivotal Trial.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Neuromodulation 2015<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

The Use Of 10-kilohertz Spinal Cord Stimulation In A Cohort Of Patients With Chronic Neuropathic Limb Pain Refractory To Medical Management.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Kapural L., et al.<\/p><\/div>\r\n

Anesthesiology 2015<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Novel 10 kHz High-frequency Therapy (hf10 Therapy) Is Superior To Traditional Low-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back And Leg Pain: The SENZA-RCT Randomized Controlled Trial.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Pain Medicine 2014<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Sustained Effectiveness Of 10 kHz High-frequency Spinal Cord Stimulation For Patients With Chronic, Low Back Pain: 24-month Results Of A Prospective Multicenter Study.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Tiede J., et al.<\/p><\/div>\r\n

Neuromodulation 2013<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Novel Spinal Cord Stimulation Parameters In Patients With Predominant Back Pain.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Van Buyten J.P., et al.<\/p><\/div>\r\n

Neuromodulation 2013<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

High-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back Pain Patients: Results Of A Prospective Multicenter European Clinical Study.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n
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Upper Limb Pain<\/h3>\r\n <\/div>\r\n
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Author<\/h5><\/div>\r\n
Source<\/h5><\/div>\r\n
Title<\/h5><\/div>\r\n
Download File<\/h5><\/div>\r\n <\/div>\r\n
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Amirdelfan K., et al.<\/p><\/div>\r\n

Neurosurgery 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

High-frequency Spinal Cord Stimulation At 10 kHz In The Treatment Of Combined Neck And Arm Pain: Results From A Prospective Multicenter Study.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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El Majdoub F., et al.<\/p><\/div>\r\n

Annals of Clinical and Translational Neurology 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

10 kHz Cervical SCS For Chronic Neck And Upper Limb Pain: 12 Months' Results.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n
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Non-Surgical Refractory Back Pain<\/h3>\r\n <\/div>\r\n
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Author<\/h5><\/div>\r\n
Source<\/h5><\/div>\r\n
Title<\/h5><\/div>\r\n
Download File<\/h5><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Anaesthesia 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

10 kHz spinal cord stimulation for the treatment of non\u2010surgical refractory back pain: subanalysis of pooled data from two prospective studies<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Patel N.<\/p><\/div>\r\n

NANS 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Taking Spinal Cord Stimulation Beyond Failed Back Surgery Syndrome: Design Of A Multicenter RCT.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Neuromodulation 2017<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

10 kHz High-frequency Spinal Cord Stimulation For Chronic Axial Low Back Pain In Patients With No History Of Spinal Surgery: A Preliminary, Prospective, Open Label, And Proof Of Concept Study.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Pain Medicine 2017<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Long-term Improvements In Chronic Axial Low Back Pain Patients Without Previous Spinal Surgery: A Cohort Analysis Of 10 kHz High-frequency Spinal Cord Stimulation Over 36 Months.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Pain Medicine 2017<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Long-term Improvements In Chronic Axial Low Back Pain Patients Without Previous Spinal Surgery: A Cohort Analysis Of 10 kHz High-frequency Spinal Cord Stimulation Over 36 Months.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Ahmadi S.A., et al.<\/p><\/div>\r\n

Neuromodulation 2017<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

High-frequency Spinal Cord Stimulation In Surgery-na\u00efve Patients-a Prospective Single-center Study.<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n
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Opioid Reduction and Quality of Life<\/h3>\r\n <\/div>\r\n
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Author<\/h5><\/div>\r\n
Source<\/h5><\/div>\r\n
Title<\/h5><\/div>\r\n
Download File<\/h5><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Annals of New York Academy of Sciences 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Opioid\u2010Sparing Effects of 10 kHz Spinal Cord Stimulation: A Review of Clinical Evidence<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Scientific Reports 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

10 kHz SCS Therapy For Chronic Pain, Effects On Opioid Usage: Post Hoc Analysis Of Data From Two Prospective Studies<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Amirdelfan K., et al.<\/p><\/div>\r\n

Quality of Life Research 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Long-term Quality Of Life Improvement For Chronic Intractable Back And Leg Pain Patients Using Spinal Cord Stimulation: 12-month Results From The SENZA-RCT<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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DiBenedetto D.J., et al.<\/p><\/div>\r\n

Journal of Pain Research 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

10 kHz Spinal Cord Stimulation: A Retrospective Analysis Of Real-World Data From A Community-Based, Interdisciplinary Pain Facility<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n
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Additional Resources<\/h3>\r\n <\/div>\r\n
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Author<\/h5><\/div>\r\n
Source<\/h5><\/div>\r\n
Title<\/h5><\/div>\r\n
Download File<\/h5><\/div>\r\n <\/div>\r\n
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Sayed D., et al.<\/p><\/div>\r\n

Journal of Pain Research 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Retrospective Analysis of Real-World Outcomes of 10 kHz SCS in Patients with Upper Limb and Neck Pain<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Kapural L., et al.<\/p><\/div>\r\n

Clinical and Translational Gastroenterology 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Treatment of Chronic Abdominal Pain With 10-kHz Spinal Cord Stimulation: Results From a 12-Month Prospective, Multicenter, Feasibility Study<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Sayed D., et al.<\/p><\/div>\r\n

CNS Neuroscience & Therapeutics 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Pain Relief and Improvement in Quality of Life with 10 kHz SCS Therapy: Summary of Clinical Evidence<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Lee K.Y., et al.<\/p><\/div>\r\n

Neuroscience 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Low-intensity, Kilohertz Frequency Spinal Cord Stimulation Differently Affects Excitatory and Inhibitory Neurons in the Rodent Superficial Dorsal Horn<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Rosenberg W. S., et al.<\/p><\/div>\r\n

NANS 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Salvage of Previously Failed Spinal Cord Stimulation Using 10 kHz SCS Through a \u2018Pocket Trial\u2019 Technique<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Russo M., et al.<\/p><\/div>\r\n

NANS 2020<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Improved Versatility and Frequency Pairing Capabilities with 10 kHz Spinal Cord Stimulation for the Treatment of Chronic Pain<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Gill, J.S., et al.<\/p><\/div>\r\n

Pain Practice 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Complex Regional Pain Syndrome: A Case Series of Patients with or Without Previous Spinal Cord Stimulator Implantation<\/a><\/div>\r\n
Link<\/a><\/div>\r\n <\/div>\r\n
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Al-Kaisy A., et al.<\/p><\/div>\r\n

Annals of New York Academy of Sciences 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Opioid\u2010Sparing Effects of 10 kHz Spinal Cord Stimulation: A Review of Clinical Evidence<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Manfield, J., et al.<\/p><\/div>\r\n

Stereotactic and Functional Neurosurgery 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Safety and Utility of Spinal Magnetic Resonance Imaging in Patients with High-Frequency Spinal Cord Stimulators: A Prospective Single-Centre Study<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Palmisani S., et al.<\/p><\/div>\r\n

NANS 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Safety and Efficacy of Cervical 10 kHz Spinal Cord Stimulation (SCS) for the Management of Refractory Chronic Migraine: A Prospective Study<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Galan V., et al.<\/p><\/div>\r\n

ASRA 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

A Prospective Clinical Trial to Assess High Frequency Spinal Cord Stimulation (HF-SCS) at 10 kHz in the Treatment of Chronic Intractable Pain from Peripheral Polyneuropathy (PPN)<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Tate J., et al.\t<\/p><\/div>\r\n

NANS 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

A Prospective, Multi-Site, Clinical Trial of the Senza\u2122 Spinal Cord Stimulation (SCS) System in the Treatment of Chronic Pelvic Pain.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Gupta M., et al.<\/p><\/div>\r\n

ASRA 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Spinal Cord Stimulation at 10 kHz for the Treatment of Chronic Focal Neuropathic Post-Surgical Pain.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Billet B., et al.<\/p><\/div>\r\n

NANS 2019<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

High Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Focal, Chronic, Post-Surgical Neuropathic Pain.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Groote S.D., et al.<\/p><\/div>\r\n

Neuromodulation 2018<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Magnetic Resonance Imaging Exploration of the Human Brain During 10 kHz Spinal Cord Stimulation for Failed Back Surgery Syndrome: A Resting State Functional Magnetic Resonance Imaging Study.<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Lambru G., et al.<\/p><\/div>\r\n

The Journal of Headache and Pain 2016<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Safety and Efficacy of Cervical 10 kHz Spinal Cord Stimulation in Chronic Refractory Primary Headaches: a Retrospective Case Series*<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n
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Arcioni R., et al.<\/p><\/div>\r\n

European Journal of Pain<\/p><\/div>\r\n \r\n \r\n \r\n \r\n \r\n \r\n

Cervical 10 kHz Spinal Cord Stimulation in The Management Of Chronic, Medically Refractory Migraine: A Prospective, Open-Label, Exploratory Study*<\/a><\/div>\r\n
PDF<\/a><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\n\n
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